A model for spasticity and contracture in Opensim: refinement and validation

Thalia Kindt
Persbericht

A model for spasticity and contracture in Opensim: refinement and validation

Cerebral Palsy (CP) is een vaak voorkomende aandoening tijdens de kinderjaren (Himmelmann et al. 2010) en gaat in 85% gepaard met spasticiteit [1]. De patiënt wordt gekenmerkt door een onwillekeurig verhoogde spierspanning of plotse spiersamentrekking, en verminderde willekeurige kracht. Spasticiteit wordt gekenmerkt door twee effecten, namelijk lengte-afhankelijkheid [2] en snelheidsafhankelijkheid [3]. Het eerstgenoemde betekent dat als men een spier verder uitrekt er meer spasticiteit optreedt. De snelheidsafhankelijkheid houdt in dat wanneer een spier sneller gerekt wordt, er meer spasticiteit zal optreden.Het doel van onze studie was deze fenomenen te integreren in een neuromusculoskeletaal model. De stijfheidsparameters van de spieren in dit model werden bepaald door passieve spierrekkingen aan verschillende snelheden te onderzoeken bij patiënten met CP. Aanpassingen aan de parameters droeg bij tot het begrip van spasticiteit. Eens dit model op punt stond, werden diezelfde spierrekkingen gesimuleerd met het model. Op deze manier werd spasticiteit in zijn zuiverste vorm onderzocht. Een gesimuleerde spieractivatie opleggen aan deze beweging leidde tot rekkingen met zuivere snelheids-afhankelijke spasticiteit. Dit project ontwikkelde dus een adequaat model voor verder spasticiteitsonderzoek. Uitbreiding van de toepassing zal gebeuren naar actieve bewegingen. Deze kennis kan een belangrijke bijdrage leveren tot het klinisch onderzoek en de behandeling van CP.Referenties[1] Himmelmann, K. Hagberg, G. Uvebrant, P. 2010. The changing panorama of cerebral palsy in Sweden. X. Prevalence and origin in the birth year period 1999-2002. Acta Paediatr 99, 1337-43.[2] Sanger TD, Delgado MR, Gaebler-Spira D, Hallett M, Mink JW. (2003) Classification and definition of disorders causing hypertonia in childhood. Pediatrics 111: 89-97.[3] Lance JW. What is spasticity? The Lancet March 10, 1990: 606.

Bibliografie

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Universiteit of Hogeschool
Revalidatiewetenschappen en Kinesitherapie
Publicatiejaar
2014
Kernwoorden
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